Observations On the Effects of Histamine and Serotonin in the Rabbit Ear Chamber

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Abstract
The effects produced by the injection of histamine and serotonin 5-Hydroxytriptamine'' in rabbit ear chambers were described. Histamine induced early arteriolar dilation and rapid venular blood flow. Early and transient rolling, sticking, and sometimes, emigration of leukocytes occurred with concentrations of histamine considerably higher than those required to cause increased vascular permeability in rabbit skin. The implications of these findings in regard to the possible role of histamine in the pathogenesis of inflammation were discussed. Serotonin administration was not associated with early inflammatory changes of the type seen after histamine. Early and relatively prolonged arteriolar dilation didoccur. The most noteworthy effect was the formation of multiple venular platelet-leukocyte thromboemboli. The possible significance of this finding was discussed.