Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19
- 1 February 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 40 (2) , 222
- https://doi.org/10.1212/wnl.40.2.222
Abstract
The myotonic dystrophy (DM) gene is localized to the proximal long arm of chromosome 19. There have been reports of tight linkage to a number of chromosome 19 markers, including APOC2 and creatine kinase muscle type (CKMM), but they did not establish orientation of the 2 markers to DM. We screened several large multi-generational DM families for linkage to a series of chromosome 19 markers including CKMM. CKMM is tightly linked to DM in these data with z(𝛉) = 28.41; 𝛉 = 0.01. Analysis of cross-over data indicates CKMM is on the same side and closer to DM than APOC2. Thus, CKMM is a useful probe for carrier detection studies in presymptomatic individuals as well as for prenatal diagnosis.This publication has 1 reference indexed in Scilit:
- The isolation and characterization of cDNA clones for human apolipoprotein CII.Journal of Biological Chemistry, 1984