SUPPRESSION OF CYTOTOXIC RESPONSE TO HISTOINCOMPATIBLE CELLS .2. ANALYSIS OF THE ROLE OF 2 INDEPENDENT-T SUPPRESSOR POOLS IN MAINTENANCE OF NEONATALLY INDUCED ALLOGRAFT TOLERANCE IN MICE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 122  (3) , 747-752
Abstract
The kinetics of appearance of the precursors of SuppA cells (capable of inhibiting CTLp [cytotoxic lymphocyte precursors] .fwdarw. CTL) or SuppB cells (capable of inhibiting stem cells .fwdarw. CTLp) in neonatal mice and the appearance of SuppA/SuppB cells in mice given neonatal inoculations of semiallogeneic spleen cells was investigated. SuppA cells may have a natural role to play in the induction of neonatal tolerance, whereas SuppB cells may be more important for the maintenance of the tolerant state. Unlike the level of SuppB cells, the level of SuppA cells in tolerant mice seems modulated by the presence of the tolerizing determinants. SuppB cells, once induced in tolerant mice, can adoptively transfer specific allograft unresponsiveness to newborn syngeneic mice in the absence of added tolerizing antigen, whereas SuppA cells are not able to do so. SuppB cells may be responsible for the phenotype of clonal deletion.

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