Asymmetric Effects of Acute Hemiovariectomy on Steroid Hormone Secretion by the In Situ Ovary

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Abstract
The acute effects of hemiovariectomy on progesterone, testosterone, estradiol, and luteinizing hormone (LH) concentrations in serum were studied in rats under the following experimental conditions: control, sham-operated (left or right), hemiovariectomized, bilateral adrenalectomized, and hemiovariectomized plus bilateral adrenalectomized. One-hour after surgery, the concentration of progesterone and testosterone in the serum of right-side sham-operated rats was significantly higher than in control animals. Testosterone concentration in serum in rats with the right ovary in situ was higher than in sham-operated animals; injecting atropine sulfate 1 h before surgery blocked such increase, while the same treatment to rats with the left ovary remaining in situ resulted in a significant increase of testosterone concentration. Adrenalectomy resulted in an increase of testosterone concentration, which was higher when atropine sulfate was injected before surgery. Our results support the idea that left and right ovaries play different roles in the regulation of hormone secretion, and that such differences are related to ovarian innervation.