Tissue specific opsonins for phagocytic cells and their different affinity for cholesterol‐rich liposomes
- 6 June 1988
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 233 (1) , 143-147
- https://doi.org/10.1016/0014-5793(88)81372-3
Abstract
In accordance with the finding of our in vivo experiments reported earlier [(1983) Biochim. Biophys. Acta 761, 142–157 (1986) Biochim. Biophys. Acta 888, 184–190], the results of in vitro experiments show that Kupffer cells avidly take up cholesterol-poor but not cholesterol-rich liposomes, whereas splenic phagocytic cells take up preferentially cholesterol-rich rather than cholesterol-poor liposomes in the presence of serum. Evidence presented here suggests that serum contains opsonins specific for hepatic and splenic phagocytic cells and these opsonins have different affinities for cholesterol-rich and cholesterol-poor liposomes.Keywords
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