The role of β-lactamase and the permeability barrier on the activity of cephalosporins against members of the Bacteroides fragilis group
- 1 March 1987
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Microbiology
- Vol. 33 (3) , 262-266
- https://doi.org/10.1139/m87-044
Abstract
The role of β-lactamase and the permeability barrier on the activity of some β-lactams against 53 strains of the Bacteroides fragilis group was investigated. Minimal inhibitory concentrations of cefamandole, cefoxitin, and cephalothin were determined with or without the addition of clavulanic acid and (or) ethylenediaminetetraacetate using an agar dilution technique. A significant increase of susceptibility with clavulanic acid indicated a role for β-lactamase, and with ethylenediaminetetraacetate, a role for a permeability barrier. We found that both β-lactamase and low permeability decreased the activity of the β-lactams to some extent depending on the bacterial species and the antibiotic. The species-specific exception was B. distasonis which showed only a permeability barrier to all antibiotics tested.This publication has 1 reference indexed in Scilit:
- Factors Contributing to Resistance to Beta-Lactam Antibiotics in Bacteroides fragilisAntimicrobial Agents and Chemotherapy, 1979