Urinary Delta-Aminolevulinic Acid (ALA) Levels in Lead Poisoning

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Abstract
The method for the determination of urinary delta-aminolevulinic acid (ALA) from random urine samples has been modified utilizing a dual disposable chromatographic column unit prefilled with resin that can be conveniently held in a support rack over a drain tray. The present procedure now permits one individual to perform as many as 1,000 analyses of urinary ALA in a normal working week. A single-blind evaluation was made of the laboratory findings and clinical impression of increased lead exposure versus the urinary ALA levels obtained in each of 250 children suspected of lead ingestion. St was found that the incidence of a correct correlation between urinary ALA and the clinical diagnosis of increased lead exposure was 91%. None of the other laboratory tests studied had a comparable degree of accuracy for the detection of early lead exposure.

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