Studies of the Putative Transforming Protein of the Type I Human T-Cell Leukemia Virus
- 21 June 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 228 (4706) , 1427-1430
- https://doi.org/10.1126/science.2990027
Abstract
The putative transforming protein of the type I human T-cell leukemia virus (HTLV-I) is a 40-kilodalton protein encoded by the X region and is termed p40 xI . On the basis of both subcellular fractionation techniques and immunocytochemical analysis, it is now shown that p40 xI is a nuclear protein with a relatively short half-life (120 minutes). It is synthesized de novo in considerable quantities in a human T-cell line infected with and transformed by the virus in vitro, and it is not packaged in detectable amounts in the extracellular virus.Keywords
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