Modification of Radiolethality by Vitamin K5 and Certain Analogs in Model Systems and in Foodsa

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Abstract
SUMMARY: Spores of Bacillus subtilis var. niger and B. stearothermophilus irradiated in nitrogen were killed in greater numbers in the presence of vitamin KC, 4.amino‐1‐naphthol, or 2‐amino‐1‐naphthol than when irradiated without chemical. When irradiation was performed in air, the chemicals were without effect, or even protective. Spores of both organisms were particularly sensitive when irradiated in nitrogen with 4‐amino‐1‐naphthol.Irradiation of Micrococcus radiodurans in anoxia with these naphthol derivatives gave losses in cell recovery that resulted in much lower populations than could he attributed to chemical toxicity per se. These chemicals were found to be toxic to a yeast that had been isolated from frozen orange juice when the preparations were in buffer of pH 7.0 and 4.0. When the yeast was suspended in orange juice, on the other hand, the chemicals were neither toxic nor radiosensitizers. Milk was also found to interfere with the bactericidal and radiolethal activities of these chemicals. Sulfhydryl compounds were shown to decrease radiolethal action.