Serum Paraoxonase Polymorphism in Three Populations of Southeast Asia
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 41 (4) , 265-269
- https://doi.org/10.1159/000154010
Abstract
Serum paraoxonase hydrolyzes paraoxon, the principal metabolite of the insecticide parathion. Serum paraoxonase is polymorphic and controlled by two codominant alleles – PON*A and PON*B representing low and high activity, respectively. Three populations of southeast Asia comprising 194 Chinese, 159 Filipinos and 73 Dravidian Indians were investigated for serum paraoxonase polymorphism. The frequency of PON*B was found to be 0.14 in the Chinese, 0.04 in the Filipinos and 0.18 in Dravidian Indians. The distribution of the PON phenotypes was at Hardy-Weinberg equilibrium in all the three populations studied.Keywords
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