Nicotinamide administration alters the activities of hepatic microsomal mixed function oxidases
- 1 November 1980
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 36 (11) , 1311
- https://doi.org/10.1007/bf01969607
Abstract
Systemic action of nicotinamide significantly alters the activities of hepatic drug metabolizing enzymes. Male rats injected with nicotinamide have reduced levels of cytochrome P450, demethylases and aniline hydroxylase. The changes appear to be sex-dependent since in the case of female rats activities of p-nitroanisole-o-demethylase and aniline hydroxylase are enhanced whereas cytochrome P450 content remains unaltered.This publication has 10 references indexed in Scilit:
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