Abstract
Filamentous axonal masses, similar to the abnormal enlargements found in the ventral horns, were found in Clarke''s nucleus in 6 patients with sporadic ALS [amyotrophic lateral sclerosis]. Clarke''s nucleus is generally thought to be normal in sporadic ALS, but the present findings, in conjunction with distal spinocerebellar degeneration which is often described, suggest that this system is also pathologically involved.

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