EFFECT OF VOLATILE ANAESTHETICS AND NITROUS OXIDE-FENTANYL ANAESTHESIA ON BLEEDING TIME

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Abstract
Patients (51) were divided randomly into 4 groups: halothane in O2; fentanyl plus nitrous oxide in O2; enflurane in O2; or isoflurane in O2. Standardized bleeding time was measured using a Simplate II bleeding device before and at least 40 min after the induction of anesthesia. Arterial pressure was maintained at .+-. 20% of control values and temperature was kept at 35-37.degree. C. The bleeding time was prolonged by 33% in the halothane group (P < 0.01) and by 20% in the nitrous oxide-fentanyl group (n.s. [not significant]). There was essentially no change in bleeding time in the groups receiving enflurane or isoflurane, although there was considerable variability within each group, which did not seem to be related to differences in sex, age, type of surgery, concentration of agent used or surgical procedure.

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