BLOOD FIBRIN STUDIES

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Abstract
When diets of known composition, in which all the components but the carbohydrate and protein portions remained constant (these 2 being substituted isocalorically, one for the other), were fed to dogs, the concentration of fibrin yielded by the blood depended upon the nature of the previous regimen and tUfe duration of its feeding. The feeding of different prdtein-containing diets caused variations in the fibrin-ogen concentration of the blood. Rations containing a high percentage of protein, when fed over long periods, did not cause the fibrin values to remain at a high level. This seems to indicate that the ingested protein acted as some sort of transient stimulus to increase fibrinogen production. When rations containing gradually increased amounts of protein were fed the concentration of fibrin yielded by the blood did not increase with each increment of protein. Apparently, the type of protein ingested did not play any marked part in determining the response elicited; similar results were obtained with the widely unlike casein and "meat residue." Rations extremely low in protein when fed over long periods also seemed to stimulate fibrinogen production. Under the experimental conditions adopted pig stomach appeared no more effective in causing changes in the fibrin values than did pig liver or kidney. In fact, the variations were no greater than those observed when casein and "meat residue" were fed. Observational periods of 10 days or longer were necessary to secure a clear cut demonstration of the effects of the special diet. Longer periods might profitably be employed, whereas short periods were likely to give an entirely erroneous picture. The daily variations in fibrin concentration, observed in some periods, were less than 10%, though usually they amounted to more than this (20-25%). The reasons for the fluctuations were still unexplained. Starvation periods of 3 to 6 days might cause minimum fibrin values. The results, however, would depend largely upon the type of diet and duration of its feeding immediately preceding the inanition. As to fibrin concentration of blood from vessel to vessel, no difference was noted between arterial (heart) and venous (jugular) blood and the variations that were noted between other vessels were mostly within the limits of experimental error.

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