Protective Role of Transforming Growth Factorβ(TGFβ) in Tumor-Induced Degradation of Basement Membranes
- 1 January 1990
- journal article
- research article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 371 (2) , 687-692
- https://doi.org/10.1515/bchm3.1990.371.2.687
Abstract
Human fibrosarcoma cells derived from a patient with multiple metastases extensively degrade artificial basement membranes (BM) and secrete interstitial type of collagenase, a proteolytic enzyme responsible for degradation of type I collagen. Exposure of invasive cell line to TGF .beta. abrogates destruction of BM. TGF .beta. reduces collagenase activity and stimulates specific metalloproteinase inhibitor (TIMP) in invasive tumor cells. We preassume that TGF .beta. could play a protective role in tumor invasion.This publication has 14 references indexed in Scilit:
- Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.The Journal of cell biology, 1986
- Opposite and selective effects of epidermal growth factor and human platelet transforming growth factor-beta on the production of secreted proteins by murine 3T3 cells and human fibroblasts.Journal of Biological Chemistry, 1986
- GROWTH OF HUMAN UROLOGICAL TUMORS ON EXTRACELLULAR-MATRIX AS A MODEL FOR THE INVITRO CULTIVATION OF PRIMARY HUMAN-TUMOR EXPLANTS1986
- An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinasesBiochemical Journal, 1981
- EFFECT OF PLASMINOGEN-ACTIVATOR (UROKINASE), PLASMIN, AND THROMBIN ON GLYCOPROTEIN AND COLLAGENOUS COMPONENTS OF BASEMENT-MEMBRANE1981
- Identification of a type V collagenolytic enzymeBiochemical and Biophysical Research Communications, 1981
- DESTRUCTION OF EXTRACELLULAR MATRICES CONTAINING GLYCOPROTEINS, ELASTIN, AND COLLAGEN BY METASTATIC HUMAN-TUMOR CELLS1980
- Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.Proceedings of the National Academy of Sciences, 1979
- Stimulation of corneal endothelial cell proliferation in vitro by fibroblast and epidermal growth factorsExperimental Eye Research, 1977