Daycare attendance, asthma and atopy.

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Abstract
The objective of this article is to review studies that have examined the relation of daycare to asthma and atopy. In order to identify studies for inclusion, abstracts of all studies referenced in Medline from January 1966 to January 2000 and in BIBSYS were searched and extracted if they included 'asthma' or 'atopy' combined with words such as 'daycare', 'nursery' or 'kindergarten'. Eight studies fulfilled the criteria of inclusion. The outcomes were asthma, skin prick test (SPT) reactivity, a positive radioallergosorbent test (RAST), hay fever, and eczema. Daycare attendance was positively associated with asthma in five of six studies including asthma. In three of these studies there was no statistically significant association between daycare and asthma. Early start in daycare protected against later asthma in one study. There was a weak, but not a statistically significant positive relation between daycare and atopy in two of three studies when SPT reactivity was used as the outcome. In children of small families early start in daycare protected against atopy. The quality of the studies varies, and they are not directly comparable. The relation between daycare attendance and asthma and atopy is unclear, and further studies designed to answer this specific research question are needed.