Studies in the Metabolism of Carrier-Free Radio-Ruthenium The Preparation and Metabolism of Nitrosyl-Ruthenium Nitro Complexes

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Abstract
Nitro complexes of nitrosyl-ruthenium have been produced by treating a solution of the nitrosyl-trinitrate of carrier-free ruthenium-106 with oxides of nitrogen. Nitrate complexes were removed by co-precipitation with ferric hydroxide, and the supernatant solution, enriched in nitro complexes was administered to rats by stomach tube. Rats were sacrificed serially for analysis of the tissues, and the ruthenium content of the excreta was also determined. About 4% of the administered ruthenium was absorbed, and one fifth of this was still retained after 28 days. Ruthenium was distributed generally throughout the body without any large difference in concentration between the tissues, except that a higher concentration was found in the kidneys. Very little ruthenium was found in the wall of the small intestine, in contrast to a previous finding that nitrato complexes of nitrosyl-ruthenium were taken up in considerable amounts.