Spindle-shaped appendages of IIIab-pyramids filled with lipofuscin: A striking pathological change of the senescent human isocortex

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Abstract
Brains from 30 mentally normal men, ranging in age from 18–90 years, were studied to assess the occurrence and development of lipofuscin-filled spindle-shaped appendages of pyramidal cell of the isocortex; these can generally be encountered in the senescent brain within layer IIIab. The number of pigmented spindles was determined in a circumscribed part of a prefrontal area revealing a close association of this conspicuous pathological alteration with growing age.