Detection of Infection with Human Immunodeficiency Virus Type 1 before Seroconversion: Correlation with Clinical Symptoms and Outcome
Open Access
- 1 April 1997
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 175 (4) , 959-962
- https://doi.org/10.1086/514000
Abstract
Early (pre-seroconversion) infection with human immunodeficiency virus type 1 (HIV-1) was identified in 50 of 267 participants in the Multicenter AIDS Cohort Study. These 50 men had a positive EIA result, which detected IgM antibody (n = 35), p24 antigen, or serum HIV RNA (n = 15) at their last “seronegative” visit. At that visit, the mean CD4 lymphocyte number (890/mm3 vs. 1038/mm3) was significantly lower than in men who subsequently seroconverted but had no evidence of early infection. The decline in CD4 cells was slower and the duration of AIDS-free time longer in the 19 men who were symptomatic in comparison to the 31 asymptomatic men with early infection, but differences were not significant.Keywords
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