Reduced Prolactin Release after Thyrotropin-Releasing Hormone in Manic Depression

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Abstract
To the Editor: The report by Maeda et al.1 of an increased prolactin response to thyrotropin-releasing hormone (TRH) during mania in four manic-depressive female patients is consistent with our own observation of a reduced prolactin secretion after TRH in 24 manic-depressive women studied during the depressive phase. Abnormal prolactin secretion after TRH has been reported previously, with conflicting results (either increased or decreased secretion)2,3 in heterogeneous groups of depressive patients, but manic-depressive patients were never studied as a group, nor were sex and ovarian status considered as a possible source of variance.In this study, 24 manic-depressive women (five . . .