EFFECTS OF A NEW GLUCOCORTICOID, OXAZACORT, ON SOME VARIABLES CONNECTED WITH BONE METABOLISM IN MAN - COMPARISON PREDNISONE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 15  (3) , 126-134
Abstract
The urinary elimination of Ca, other electrolytes and hydroxyproline and the oral absorption of 47Ca were evaluated in 3 groups of 8 patients before and during a 15 day treatment with prednisone at daily doses of 25 and 50 mg and with oxazacort, a new [anti-inflammatory] glucocorticoid, at a daily dose of 50 mg. Oxazacort in short-term treatment with a high dose has no significant effect on the urinary Ca and hydroxypyroline elimination in experimental conditions in which prednisone produces statistically significant and clinically relevant increase, both when given at the same dose and when given at half that dose. The oral absorption of 47Ca is decreased by oxazacort, but less than by prednisone at the same dose. As the antirheumatic activity of oxazacort appears to be only slightly lower than that of prednisone (activity ratio of about 0.84:1), these findings may have interesting therapeutic implications.

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