Chronic malarial infection in Balb/c mice. Effect on the immune response to sheep erythrocytes and histological changes in the liver and spleen
- 1 January 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 69 (5-6) , 468-470
- https://doi.org/10.1016/0035-9203(75)90099-1
Abstract
Chronic malarial infection was established in Balb/c mice by following Plasmodium berghei yoelii with P.b. berghei infection. It was found that the IgG plaque-forming cell response to sheep erythrocytes was depressed for at least six months. A preliminary investigation of the histological changes in the spleen and liver is described. The possibility that chronically infected mice could serve as a model for the tropical splenomegaly syndrome is discussed.Keywords
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