Heterotransplantation of Rous Sarcoma and Rous Sarcoma Virus to Mammals

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Abstract
The intra-muscular injection of freeze dried Rous chicken sarcoma (FDS) in mice yielded the highest percentage of tumors while intraperitoneal injections resulted in a lower percentage of ascites tumors and subcutaneous injections caused tumors of small size. Oral administration of fresh material or freeze dried Rous sarcoma resulted in virus infection without tumor growth and shortened survival time due to lung hemorrhage and atrophy of the spleen. A group of 80 mice fed for 22 days on mashed bread mixed with Rous sarcoma material developed 5 tumors only two of which could be retransplanted retro-peritoneally in chicks. The sediment of the supernatant of minced fresh sarcoma obtained by centrifugation at 5,000 R and 18,000 R administered subcutaneously, intraperitoneally or orally resulted in tumor formation by all routes but least active was the supernatant at 18,000 R. Other studies involved the activity of some hormones on the development of these tumors.