Many Transcription Factors Interact Synergistically with Steroid Receptors
- 9 December 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 242 (4884) , 1418-1420
- https://doi.org/10.1126/science.3201230
Abstract
Progesterone (PRE) or glucocorticoid receptor (GRE) DNA binding sites are often found clustered with binding sites for other transcription factors. Individual protein binding sites were tested without the influence of adjacent factors by analyzing isolated combinations of several transcription factor binding sites with PREs or GREs. All show strong synergistic effects on steroid induction. The degree of synergism is inversely related to the strength of the GRE. Thus, a steroid responsive unit can be composed of several modules that, if positioned correctly, act synergistically.Keywords
This publication has 32 references indexed in Scilit:
- Synergism of closely adjacent estrogen-responsive elements increases their regulatory potentialJournal of Molecular Biology, 1988
- Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virusCell, 1988
- Human CCAAT-binding proteins have heterologous subunitsCell, 1988
- GAL4 activates gene expression in mammalian cellsPublished by Elsevier ,1988
- Association of DNA-bound progesterone receptorsNature, 1987
- Gene regulation by proteins acting nearby and at a distanceNature, 1986
- STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKSAnnual Review of Genetics, 1985
- Steroid Hormone Regulation of Gene ExpressionAnnual Review of Pharmacology and Toxicology, 1985
- Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed regionCell, 1983
- The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virusNature, 1983