A hybrid supervisory knowledge-based system for monitoring penicillin fermentation
- 1 January 2000
- conference paper
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- Vol. 28 (07431619) , 3944-3948 vol.6
- https://doi.org/10.1109/acc.2000.876962
Abstract
Batch and fed-batch bioprocesses generally exhibit batch-to-batch variation. Multivariate statistical monitoring of these processes based on the use of empirical models developed from the multiway principal component analysis was performed by using contribution, T/sup 2/ and square prediction error plots. To cope with uncertainties in the fermentation process and to provide more effective supervision, a knowledge-based system was developed allowing the coupling of quantitative statistical information with the qualitative domain expertise (heuristic knowledge). This hybrid system (PenExpert) aims to perform old-of-batch process monitoring as well as online process monitoring and fault diagnosis.Keywords
This publication has 12 references indexed in Scilit:
- Adaptive batch monitoring using hierarchical PCAChemometrics and Intelligent Laboratory Systems, 1998
- Synchronization of batch trajectories using dynamic time warpingAIChE Journal, 1998
- Multivariate statistical methods in bioprocess fault detection and performance forecastingTransactions of the Institute of Measurement and Control, 1997
- Statistical process monitoring and disturbance diagnosis in multivariable continuous processesAIChE Journal, 1996
- Monitoring batch processes using multiway principal component analysisAIChE Journal, 1994
- Artificial intelligence and the supervision of bioprocesses (real-time knowledge-based systems and neural networks)Published by Springer Nature ,1993
- A Use's Guide to Principal ComponentsPublished by Wiley ,1991
- A knowledge-based pattern recognition approach for real-time diagnosis and control of fermentation processes as variable structure plantsIEEE Transactions on Systems, Man, and Cybernetics, 1991
- Multi-way principal components-and PLS-analysisJournal of Chemometrics, 1987
- Performance tradeoffs in dynamic time warping algorithms for isolated word recognitionIEEE Transactions on Acoustics, Speech, and Signal Processing, 1980