The Appearance of an Endometrial 20α-Hydroxysteroid Dehydrogenase towards the End of Pregnancy in the Rat

Abstract
Rates of 3α-, 5α- and 20α-reduction of progesterone have been measured in homogenates of rat uterus at varying stages of gestation. The activity of 5α-reductase was low at days 14-16 and increased 2.5-fold before the end of pregnancy. The activity of 20α-hydroxysteroid dehydrogenase increased 3.5-fold during the latter half of gestation. Removal of endometrium by scraping indicated this increase was limited to the endometrium.(Endocrinology92: 624, 1973)

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