Aconitine Induced Pulmonary Edema.

Abstract
Injections of aconitine bilaterally into the preoptic areas of rats in doses of 0.2 to 0.02 micrograms resulted in the development of fatal pulmonary edema. The edema developed in the presence of either, fluothane or light barbiturate anesthesia. The amount of edema was reduced but not abolished by deep barbiturate anesthesia and by lesions of the posterior hypothalamus. Systemic injection of the drug up to fatal doses did not produce pulmonary edema.

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