Fluorinated nitrogen heterocycles via cyclization. III. 3‐trifluoromethyl‐1‐(4‐trifluoromethyl‐2‐pyridyl)‐pyrazoles from fluorinated 1,3‐diketones and 4‐trifluoromethyl‐2‐hydrazinopyridines
- 1 April 1969
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 6 (2) , 223-228
- https://doi.org/10.1002/jhet.5570060213
Abstract
Fluorinated 1,3‐diketone compounds having the general structure CF3COCH2COR1 underwent cyclization with 4‐trifluoromethyl‐2‐hydrazinopyridines (IV) to give a series of 3‐trifluoro‐methyl‐1‐(4‐trifluoromethyl‐2‐pyridyl)‐pyrazoles (V). The hydrazinopyridine intermediates (IV) were prepared by conversion of 4‐trifluoromethyl‐2‐pyridones (II) to the chloropyridines (III) followed by treatment of the latter with hydrazine hydrate.Keywords
This publication has 8 references indexed in Scilit:
- Fluorinated nitrogen heterocycles via cyclization. II. 3‐trifluoromethylglutarimides from fluorinated α,β‐unsaturated carbonyls and cyanoacetamideJournal of Heterocyclic Chemistry, 1966
- Fluorinated Nitrogen Heterocycles via Cyclization. I. Trifluoromethyl-2-pyridones from Fluorinated 1,3-Dicarbonyls and CyanoacetamideThe Journal of Organic Chemistry, 1965
- Beriberi heart diseaseAmerican Heart Journal, 1965
- The Antidiabetic Activity of 3,5-DimethylpyrazolesJournal of Medicinal Chemistry, 1964
- Chlorodehydroxylation of Nitrogen Heterocycles with Phenylphosphonic DichlorideJournal of the American Chemical Society, 1958
- The Synthesis of Some DimethoxymethylpyridinesJournal of the American Chemical Society, 1951
- The Preparation and Reactions of Some Polysubstituted Pyridines. 2-Methyl-3-hydroxy-5-hydroxymethylpyridine (4-Deshydroxymethylpyridoxin)Journal of the American Chemical Society, 1947
- Synthesis of Vitamin B6. IIJournal of the American Chemical Society, 1939