Inhibition of protein synthesis by the cordycepin analog of (2′–5′)ppp(Ap)nA, (2′–5′)ppp(3′dAp)n3′ dA, in intact mammalian cells
- 27 June 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 157 (1) , 205-209
- https://doi.org/10.1016/0014-5793(83)81146-6
Abstract
The introduction of the cordycepin analog of (2′–5′)An, (2′–5′)ppp(3′ dAp)n3′ dA [referred to as (2′–5′)p33′ dAn], into mouse L929 cells and cultured human fibroblasts resulted in a dose-dependent inhibition of protein synthesis which was comparable to the inhibition observed by (2′–5′)ppp(Ap)nA [referred to as (2′–5′)p3An]. The inhibition of protein synthesis by (2′–5′)p33′ dAn was much more persistent than that of the naturally occurring (2′–5′)p3An following prolonged incubation of cells. Furthermore, the (2′–5′)p3An was cytotoxic to mammalian cells in culture, whereas the (2′–5′)p33′dAn was notKeywords
This publication has 15 references indexed in Scilit:
- Enzymatic synthesis of the 2′,5′-A4 tetramer analog, 2′,5′-ppp3′dA(p3′dA)3, by rabbit reticulocyte lysates: Binding and activation of the 2′,5′-An dependent nuclease, hydrolysis of mRNA, and inhibition of protein synthesisBiochemical and Biophysical Research Communications, 1983
- Structural requirements of (2′–5′) oligoadenylate for protein synthesis inhibition in human fibroblastsNucleic Acids Research, 1982
- Mechanism of Interferon Action: Progress toward Its UnderstandingProgress in Nucleic Acid Research and Molecular Biology, 1982
- Core (2'-5')oligoadenylate and the cordycepin analog: inhibitors of Epstein--Barr virus-induced transformation of human lymphocytes in the absence of interferon.Proceedings of the National Academy of Sciences, 1981
- Synthesis and characterization of (2′-5′)ppp3′dA(p3′dA)n, an analogue of (2′-5′)pppA(pA)nNature, 1981
- [33] Enzymic synthesis of (2′-5′)ppp3′dA(p3′dA)n, the cordycepin analog of (2′-5′)-oligoadenylic acidPublished by Elsevier ,1981
- Anticellular and antiviral effects of pppA(2′p5′A)nVirology, 1980
- Metabolic stability of 2′ 5′oligo (A) and activity of 2′ 5′oligo (A)-dependent endonuclease in extracts of interferon-treated and control HeLa cellsNucleic Acids Research, 1979
- Synthesis and Breakdown of pppA2′p5′A2′p5′A and Transient Inhibition of Protein Synthesis in Extracts from Interferon‐Treated and Control CellsEuropean Journal of Biochemistry, 1978
- Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cellsNature, 1977