Effect of Epinephrine on Cyclic AMP Levels and Adenylate Cyclase and Phosphodiesterase Activities in Control and Antigen-Sensitized Guinea Pig Lungs

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Abstract
Cyclic[c]AMP levels and adenylate cyclase and phosphodiesterase activities were measured in control and ovalbumin-sensitized guinea pig lungs. cAMP levels were raised by epinephrine (0.01-10 .mu.g/ml) in both control and sensitized lungs; the response being larger in the former group. Epinephrine (10-9-10-6 M) stimulated adenylate cyclase in sensitized but had only a minimal effect in control preparations. Phosphodiesterase activities were equal in both groups. The hypersensitivity of adenylate cyclase response to epinephrine concurrent with diminished accumulation of cAMP in sensitized guinea pigs indicate that antigen sensitization alters the response of the cAMP system to epinephrine.

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