Immunological unresponsiveness of neonatal rats to infection with Nippostrongylus brasiliensis. The competence of neonatal lymphoid cells in worm expulsion.

Google Scholar
  • 1 July 1973
    • journal article
    • Vol. 25  (1) , 141-50
Abstract
Mesenteric lymph node cells obtained from adult DA rats infected with Nippostrongylus brasiliensis caused expulsion of the parasite in syngeneic neonatal recipients. On the other hand, lymphocytes obtained from infected neonatal rats failed to cause expulsion of the parasite when transferred to adult syngeneic recipients. These studies show that neonatal lymphocytes are not competent to initiate worm expulsion and this may be due to impairment as a result of tolerance or to deficiency as a result of delayed ontogeny of the immune response.

This publication has 18 references indexed in Scilit: