Influence of Transplacentally Acquired Antibody on Neonatal Susceptibility to Canine Distemper Virus in Gnotobiotic Dogs
- 30 April 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 137 (5) , 605-608
- https://doi.org/10.1093/infdis/137.5.605
Abstract
In utero acquisition of protective levels of neutralizing antibody to canine distemper virus (CDV) was observed in four litters of colostrum-deprived gnotobiotic and specific-pathogen-free puppies. Pregnant bitches with high antibody titers passively transferred antibody to these pups transplacentally in average titers of 1:7 to 1:16 per litter. Maternally derived antibody protected neonatal pups from otherwise fatal infection with virulent CDV. Protection was associated with a transient lymphopenia and viremia and temporary suppression of lymphocyte responses to phytohemagglutinin-P.Keywords
This publication has 1 reference indexed in Scilit:
- Age-Related Susceptibility to Infection with Canine Distemper Virus in Gnotobiotic DogsThe Journal of Infectious Diseases, 1976