Spontaneous Rhythmic Contraction of Separated Heart Muscle Cells
- 27 March 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 167 (3926) , 1727-1729
- https://doi.org/10.1126/science.167.3926.1727
Abstract
Muscle cells that contract spontaneously and rhythmically can be obtained from adult mouse myocardium. Contractions are observed immediately after homogenization in a solution that is ionically similar to intracellular fluid. Contraction frequency varies directly with temperature and decreases as a function of time after homogenization. At 16°C rhythmic relaxation and contraction occur for about 20 minutes. Contractions are dependent on the presence of adenosine triphosphate in the homogenization medium.Keywords
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