3-Cyanocephems and carbon-13 heterocyclic-substituted cephems via 1,3-dipolar cycloadditions
- 1 April 1976
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (4) , 562-565
- https://doi.org/10.1021/jm00226a027
Abstract
The transformation is described of 3-formylcephem 1 into its oxime, substituted oximes, and substituted hydrazones and, thence, into the 3-cyano, 3-diazomethyl, and 3-oxonitrilomethyl derivatives. These reactive 1,3-dipoles undergo 1,3-dipolar cycloadditions with various dipolarophiles to give C-3 heterocyclic-substituted cephems.Keywords
This publication has 0 references indexed in Scilit: