Relative Effectiveness of Phenothiazine Tranquilizing Drugs Causing Release of MSH.
- 1 January 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 106 (1) , 88-90
- https://doi.org/10.3181/00379727-106-26246
Abstract
Nine phenothiazine ataraxic drugs were found to cause melanophore dispersion in the intact frog; one drug was shown to be ineffective. All drugs tested in hypophysectomized animals were without effect. The drugs, therefore, are effecting the release of MSH by direct action on the hypophysis or indirectly via brain centers. Minimal effective doses of the drugs were correlated with substitutions on the phenothiazine nucleus. A parallel with milligram potency for therapeutic control of psychiatric disorders is noted.Keywords
This publication has 1 reference indexed in Scilit:
- The pigmentary effector system. VI. The dual character of endocrine co-ordination in amphibian colour changeProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1931