Myelodysplasia Progressing to Acute Myeloblastic Leukemia in an HTLV-III Virus-Positive Homosexual Man with AIDS-Related Complex
Open Access
- 1 December 1986
- journal article
- case report
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 86 (6) , 788-791
- https://doi.org/10.1093/ajcp/86.6.788
Abstract
Myelodysplastic changes have recently been described in patients with the acquired immunodeficiency syndrome (AIDS). The authors report a patient with AIDS-related complex and myelodysplasia who rapidly progressed to acute myeloblastic leukemia. Infection with human T-cell lymphotropic virus type III (HTLV-III) was documented by culture and by serology. Chromosome studies showed monosomy of chromosome 7 and structural abnormality of the long arm of chromosome 3. The association of HTLV-III infection with myelodysplasia and acute myeloblastic leukemia may have been coincidental in this reported case, but it is also possible that the leukemia was secondary to the HTLV-III infection. Further investigation appears justified.Keywords
This publication has 0 references indexed in Scilit: