Convenient syntheses of (2R,3S,4R)-3-(tert-butyldimethylsilanyloxy)-2,4-dimethyl-5-oxopentanoic acid methoxymethylamide from methacrolein. Preparation of C1–C7 and C17–C24 fragments of (+)-discodermolide
- 21 June 2002
- journal article
- Published by Elsevier in Tetrahedron: Asymmetry
- Vol. 13 (11) , 1161-1165
- https://doi.org/10.1016/s0957-4166(02)00261-6
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells???preliminary comparisons to paclitaxelAnti-Cancer Drugs, 1998
- The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant CellsMolecular Pharmacology, 1997
- Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agentsBioorganic & Medicinal Chemistry, 1996
- (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrestChemistry & Biology, 1996
- Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol,Biochemistry, 1996
- Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolidesChemistry & Biology, 1994
- Immunosuppression by DiscodermolideAnnals of the New York Academy of Sciences, 1993
- DISCODERMOLIDE—A NEW, MARINE-DERIVED IMMUNOSUPPRESSIVE COMPOUNDTransplantation, 1991
- DISCODERMOLIDE—A NEW, MARINE-DERIVED IMMUNOSUPPRESSIVE COMPOUNDTransplantation, 1991
- Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissolutaThe Journal of Organic Chemistry, 1990