Glucagon and glicentin immunoreactivity are topologically segregated in the α granule of the human pancreatic A cell
- 1 March 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 284 (5751) , 66-67
- https://doi.org/10.1038/284066a0
Abstract
Glicentin is a 100-amino acid polypeptide purified from the porcine intestine and containing the immunodeterminants of glucagon. We have previously reported the presence of glicentin immunoreactivity in the glucagon-containing, specific secretory granules (alpha granules) of the pancreatic and gastric A cell. With an improved immunocytochemical probe, the protein A-gold (pAg) technique, we are now able to show that glucagon and glicentin-like material are topologically segregated in the alpha granule of the human pancreatic A cell.Keywords
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