Effect of cimetidine on human leukocyte function

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Abstract
In vitro studies of the effects of cimetidine on neutrophil and monocyte chemotaxis revealed no differences between the treated cells and control cells. In vitro studies were performed on neutrophils and monocytes from 20 patients who were treated with oral cimetidine for duodenal ulcer disease. Neutrophil studies from these patients revealed no effect by cimetidine. A significant augmentation of chemotaxis was found in monocytes from patients receiving the drug. Studies of neutrophil phagocytosis from cimetidine-treated patients were exactly identical to control values. These studies indicate cimetidine to have a stimulatory effect on monocyte chemotaxis and no effect on neutrophil function.