Pharmacokinetics of cefazolin in patients with normal and impaired renal function

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Abstract
Intramuscular doses of 0.5 g cefazolin were given to 17 patients with varying degrees of reduced renal functions. There was no appreciable lag time before the start of absorption. In the patients with glomemlar filtration rates above 90 ml/min, the peak values ranged from 23 to 51 μg/ml which occurred 0.5 to 3.5 h after the dose. The mean peak concentration was 31 μg/ml. Absorption rate was not appreciably influenced by renal function. The elimination rate was markedly influenced by reductions in renal function. With glomerular filtration rates above 90 ml/min the serum half-life was 2.0±0.7 h. At 20 ml/min, the half-life was some 10 h. Below 10 ml/min the biliary route appears to assume the major responsibility for excretion. With creatinine clearance values below 5 ml/min, half-life values have varied between 15 and 45 h. The distribution volume was 12.81±7.15 1 which corresponds approximately to the extra-cellular fluid volume.

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