Sodium balance after adrenal enucleation

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Abstract
To better define the relationship between adrenal enucleation (AE), sodium retention and adrenal regeneration hypertension (ARH), daily Na balance was measured in rats after bilateral adrenal enucleation with (AEN) and without uninephrectomy (AE), and before and after ARH development, along with the appropriate control groups. Both AE and AEN groups retained Na during 7 days after surgery; AE 1.16 .+-. 0.24 and AEN 1.32 .+-. 0.33 meq/100 g body wt. Sham-operated, uninephrectomized rats and AE rats treated with spironolactone were in zero Na balance. In the AEN rats after the development of ARH (blood pressure > 150 torr), zero Na balance was also noted. Only AEN rats developed hypertension while sham-operated, uninephrectomized rats and AE rats with both kidneys remained normotensive for 28 wk. For 1 wk after AE, rats are in positive sodium balance; this is reversed by spironolactone but not by uninephrectomy.