Diversifying Vancomycin via Chemoenzymatic Strategies
- 18 March 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (8) , 1513-1515
- https://doi.org/10.1021/ol0501626
Abstract
The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.Keywords
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