Electrical activity of artificial ion channels incorporated into planar lipid bilayers
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 8,p. 1469-1472
- https://doi.org/10.1039/a701060e
Abstract
The ion transport ability in a planar lipid bilayer of a 21 amino acid peptide bearing six 21-crown-7 side chains is reported. The compound was designed to form an artificial ion channel by stacking the crown rings, when adopting an α-helical conformation in a bilayer membrane. All the derivatives of 1 exhibited membrane conductivity with the best results obtained with the unprotected analog 4. The latter showed typical single channel activity.Keywords
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