Collagen Age and Platelet Aggregation

Publisher Website
Google Scholar
Abstract
Rat tail tendon collagen-initiated platelet [human] aggregation exhibits a collagen age-dependent lag time. This lag time is an inverse function of the previously determined rate of fibril formation of collagen, and corresponds to the elapsed time necessary to form a collagen fibril of requisite size under the platelet aggregation conditions chosen. Such fibers exhibit native spacing and appear to be 45-90 .ANG. in diameter. Fibers preformed to that size (< 2 min for 21- to 1,100-day-old collagen), no matter what the age of the collagen, give rise to identical platelet aggregations. Fibers formed after more prolonged incubation, .gtoreq. 20 min, had impaired platelet aggregating ability.

This publication has 2 references indexed in Scilit: