C‐rasH and ornithine decarboxylase are induced by oestradiol‐17β in the mouse uterine luminal epithelium independently of the proliferative status of the cell
- 17 February 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 196 (2) , 309-314
- https://doi.org/10.1016/0014-5793(86)80269-1
Abstract
Oestradiol‐17 β (E2) treatment of the ovariectomized mouse results in a synchronised wave of cell proliferation in the uterine luminal epithelium. At the peak of DNA synthesis the mRNA level of the c‐ras H protooncogene and ornithine decarboxylase were significantly increased. Progesterone treatment completely inhibits the E2 induced wave of DNA synthesis but does not greatly influence the level of these 2 mRNAs. Thus in the uterine luminal epithelium E2 regulates the level of ornithine decarboxylase and c‐ras H independently of cell proliferation.Keywords
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