Anti-Fibrinolytic Effect of isin-Aminocaproic Acid as Measured by in vivo Clot Lysis.

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Abstract
Summary The in vivo anti-fibrinolytic properties of ∊-aminocaproic acid (EACA) were measured in rats by studying the effect of orally administered EACA on retention of subcutaneous rat plasma clots labeled with either I131-fibrinogen or I131-antibody to fi-brinogen. Five percent EACA in drinking water was found to be a better fibrinolytic inhibitor than 2% EACA; predosing with EACA did not further enhance fibrinolytic inhibition; and the EACA-induced anti-fibrinolytic state was shown to be initiated and terminated within hours after initiation and cessation, respectively, of EACA treatment. Results obtained support the hypothesis that EACA is a potent fibrinolytic inhibitor in vivo, as well as in vitro.