Platelets and the arterial wall lesion
- 1 October 1992
- journal article
- atherosclerosis
- Published by Wolters Kluwer Health in Current Opinion in Lipidology
- Vol. 3 (5) , 334-348
- https://doi.org/10.1097/00041433-199210000-00007
Abstract
Blood platelets have been shown to be intimately involved in atherosclerosis. Platelet secretory products can affect various functions and properties of arterial wall cells, such as the vasoconstriction of endothelial cells, smooth muscle cell proliferation and cholesterol metabolism in monocyte-derived macrophages. Macrophage cholesterol accumulation and foam cell formation, the hallmarks of the atherosclerotic process, can be significantly affected by blood platelets, either directly or via their effect on the interaction of cells with LDL or oxidized LDL.Keywords
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