DERMATITIS OCCURRING DURING THERAPY WITH TRIPELENNAMINE HYDROCHLORIDE ("PYRIBENZAMINE HYDROCHLORIDE")

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Abstract
It has been discovered that most of the so-called "miracle drugs" introduced during the past few decades have had the potentiality of causing cutaneous reactions. The dermatoses resulting from the therapeutic application of the trivalent arsenobenzols, penicillin, the sulfonamide compounds and dinitrophenol, have limited the usefulness of these agents. However, to date there have been no reports of dermatoses due to the antihistamine drugs, such as diphenhydramine hydrochloride ("Benadryl hydrochloride" N. N. R.) and tripelennamine hydrochloride ("pyribenzamine hydrochloride" N. N. R.).1 Therefore the 2 following cases are reported. REPORT OF CASES Case 1.— K. S., a white man aged 28, had suffered with atopic eczema since infancy. On examination on July 7, 1946 the patient presented an erythematous, pigmented, lichenified dermatitis involving the face, the neck and the flexures of the arms and legs. Treatment with diphenhydramine hydrochloride was attempted. An oral dose of 50 mg. of the drug

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