Experimental cryosurgery of the nasal mucosa in normal guinea pigs and in animals with drug-induced vasomotor rhinopathy showed complete closure of the initial ulceration by a temporary atypical epithelium within 2 weeks. 3–4 weeks after cryotreatment, normal ciliated epithelium covered the whole area. Within 4–5 weeks, the last signs of inflammatory reaction disappeared. The treatment resulted in a definitive reduction of mucosal thickness, and in a numerically significant loss of vessels and glandular acini. The histopathological results thus agreed with the clinical objective of the treatment in vasomotor rhinopathy (reduction of the nasal resistance and diminution of rhinorrhea).