Contrasting effects of spontaneous and induced cardiomyopathy on the nucleoproteins of turkey hearts

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Abstract
The possible involvement of nuclear proteins in the pathogenesis of cardiomyopathy was studied in a spontaneously occurring and a furazolidone-induced model of turkey cardiomyopathy. Both models are characterised by cardiac hypertrophy and dilatation, systemic hypotension and depressed contractility. The protein composition of myocardial nuclei was compared in normal (n=9) and cardiomyopathic (spontaneous n = 6, furazolidone-induced n=21) turkeys. Cardiac nuclei from spontaneously myopathic animals had a higher histone content (1.827±0.058 (mean±SD) mg·mg DNA−1vs 1.688±0.187 in controls, Pvs 0.882±0.128 in controls, P32P·mg prot−1.15 min−1vs 8.456±0.886 in controls, P<0.01). In contrast, furazolidone-induced cardiomyopathy of similar severity to the spontaneously occurring model was not associated with changes in nucleoprotein composition or degree of phosphorylation. These results indicate that development of spontaneous cardiomyopathy in turkeys may be related to the composition and function of nuclear nonhistone proteins. These changes are not secondary to the cardiac hypertrophy/dilatation accompanying the myopathic process.

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